Turkish Journal of Surgery

Turkish Journal of Surgery

ISSN: 2564-6850
e-ISSN: 2564-7032


Samet Yardımcı1, İlter Özer2, Tahsin Dalgıç2, Nesrin Turhan3, Erdal Birol Bostancı2

1Department of General Surgery, Marmara University Pendik Training and Research Hospital, İstanbul, Turkey
2Department of Pathology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
3Gastroenterology Surgery, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey


Malignant insulinomas are infrequent endocrine tumors with miscellaneous clinical courses. In this report, we present a rare case of insulinoma that recurred with solitary hepatic metastasis 15 years after the initial resection of the primary tumor from the pancreas. A 20-year-old woman first presented with the symptoms of hypoglycemia in 1996. The diagnosis of pancreatic insulinoma was confirmed by laboratory findings, and the initial surgery had been performed involving complete enucleation of the pancreatic mass. Histopathologically, the tumor was diagnosed as a benign adenoma. After 15 years, the patient experienced symptoms of hypoglycemia again, and laboratory findings and abdominal computed tomography identified a lesion in the liver. Intraoperative ultrasound did not show any lesion in the pancreas, and wedge resection was performed for the hepatic lesion. Postoperative blood glucose levels returned to normal. Histopathologic examination confirmed the diagnosis of liver metastasis of a neuroendocrine tumor. This is the longest interval between primary tumor and the metastasis reported in the literature, for insulinoma. Thus, it should be remembered that long-term follow-up is mandatory for the patients with insulinoma even after resection of the primary tumor. Resection is recommended when a metastatic lesion is observed.

Keywords: Insulinoma, pancreas, liver, metastasis

Cite this paper as: Yardımcı S, Özer İ, Dalgıç T, Turhan N, Bostancı EB. Symptomatic hepatic metastasis of insulinoma 15 years after pancreatic resection. Turk J Surg 2018 34 (3): 240-242


Peer Review

Externally peer-reviewed.

Author Contributions

Concept - S.Y., E.B.B.; Design - S.Y, İ.Ö.; Supervision - E.B.B.; Resource - S.Y.; Materials - N.T., T.D.; Data Collection and/or Processing - S.Y., T.D.; Analysis and/or Interpretation - İ.Ö.; Literature Search - S.Y.; Writing Manuscript - S.Y., İ.Ö.; Critical Reviews - E.B.B.

Conflict of Interest

The author have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.