Turkish Journal of Surgery

Turkish Journal of Surgery

ISSN: 2564-6850
e-ISSN: 2564-7032


Mustafa Özsoy1, Enes Şahin2, Mustafa Yavuz3, Zehra Özsoy4, Nazan Okur5, Süleyman Şahin1, Sezgin Yılmaz6, Yüksel Arıkan6

Keywords: Appleby, celiac artery, iliac–hepatic bypass, pancreas


Surgery is the only treatment method in pancreatic cancer. Unfortunately, metastatic diseases or invasion of the main vascular structures are observed in a majority of cases at the time of diagnosis; these structures originate from the body, neck, and tail of the pancreas and are considered inoperable. The first celiac artery resection for the treatment of cancer was described by Appleby in 1953. Here, we describe our hepatic artery reconstruction technique in a case with pancreatic body cancer. A 37-year-old male patient was admitted to our emergency department owing to syncope. The patient was diagnosed with acute renal failure secondary to fluid loss. Thereafter, his general condition was stable and laboratory results improved. Abdominal computed tomography was performed. Pancreatic cancer originating from the pancreatic body was detected. A pancreatic biopsy was performed and neoadjuvant gemcitabine and paclitaxel chemoradiotherapy were initiated. Surgical treatment was recommended for the identification of regression after neoadjuvant chemoradiotherapy. Following intraoperative Doppler ultrasonography, en bloc distal pancreatectomy and splenectomy involving the celiac artery trunk and total gastrectomy were performed. However, the surgical margin reliability in a frozen section revealed that the tumor was still present. Therefore, the surgical procedure was replaced with total pancreaticoduodenectomy. The hepatic artery reconstruction was performed from the left main iliac artery using a 4-mm ringed GORE-TEX® graft. The iliac–hepatic bypass for hepatic artery reconstruction in pancreatic cancer could be an alternative surgical technique.


Surgery is the only treatment method that is known to prolong survival in pancreatic cancer, which is one of the most lethal types of cancer. In the standard treatment of cancer originating from the pancreas’ body, splenectomy and distal pancreatectomy are involved; however resection of the main vascular structures, such as the celiac artery and main hepatic artery, is required to achieve a curative resection (R0) in most cases (1). Unfortunately, there are limited data available on celiac artery resection in cancer of the pancreatic body. Here, we describe our novel hepatic artery reconstruction technique after switching from the Appleby procedure to total pancreaticoduodenectomy in a patient with pancreatic body cancer, as an intraoperative frozen section revealed that the tumor remained at the surgical margin.

Case Presentation

A 37-year-old male patient was admitted to emergency department owing to syncope. The patient had lost about 30 kg of weight with increasingly sever abdominal pain in the 3 months before admission. Laboratory tests revealed elevated aspartate aminotransferase (100 U/L), alanine aminotransferase (80 U/L), and creatinine (2.7 mg/dL); an international normalized ratio of 1.8; and CA19-9 of 200 U/mL. In a focused assessment using sonography for trauma of the abdomen, no free fluids were detected; however, an approximately 6-cm mass of pancreatic origin was observed in the upper abdomen. The patient was admitted to the intensive care unit due to acute renal failure secondary to fluid loss. His general condition was stable and laboratory results improved. In a dynamic upper abdominal computed tomography scan, pancreatic cancer that showed no distant organ or peritoneal spread was detected in the splenic, hepatic, and celiac artery originating from the pancreatic body (Figure 1). Additional focus was detected in a positron emission tomography scan. A pancreatic biopsy was performed under the guidance of ultrasonography (USG), and neoadjuvant gemcitabine and paclitaxel chemoradiotherapy were initiated. The surgical treatment was recommended upon the identification of regression after neoadjuvant chemoradiotherapy.

A written informed consent was obtained from the patient. No distant organ metastasis was noted in an abdominal exploration. The mesenteric artery and vein were suspended through an extended Kocher maneuver. The hepatoduodenal ligament was dissected and the main hepatic artery, portal vein, and bile duct were suspended. The pancreas was transected from the retropancreatic portal vein level. The main hepatic artery was clamped, and the peak systolic velocity of the hepatic artery was measured as normal (58.60 mL/min) using intraoperative Doppler USG. Following the intraoperative Doppler USG and macroscopically adequate hepatic artery pulsation, en bloc distal pancreatectomy and splenectomy, including the celiac artery trunk, and total gastrectomy, were performed. The examination of the specimen sent for surgical margin reliability revealed that the tumor was still present; therefore, we decided to perform pancreaticoduodenectomy. Conventional pancreaticoduodenectomy was completed with gastroduodenal artery connection following a choledochal dissection. Due to the presence of acute renal failure in the patient’s history, a hepatic artery reconstruction was performed from the left main iliac artery with the help of a 4-mm ringed GORE-TEX® (W. L. Gore & Associates, Flagstaff, Arizona, USA) graft to minimize the risk of renal ischemia due to aortic clamping. The total duration of the ischemia was 25 min. The hepatic artery flow was 60 mL/min in the repeated Doppler USG (Figure 2). Reconstruction was completed with hepaticojejunostomy and esophagojejunostomy. In the post-operative period, the blood sugar level of the patient was regulated, and he was coumadinized and discharged on Day 15 following the operation (Figure 3). In the post-operative histopathological examination, all surgical margins were found to be negative for tumors. The adjuvant therapy was completed, and the patient is cancer-free and still alive at 22 months after the operation.


Despite the developments in surgical, adjuvant, and neoadjuvant radiochemotherapy regimens for the treatment of pancreatic cancer, the five-year survival rates are still below the desired targets. In the study by Sohn et al. (2), only 10%–30% of pancreatic cancer patients were reported to be eligible for the surgical treatment. Despite a theoretically possible curative (R0) resection due to the resection of major vascular structures and complex reconstructive surgical interventions in locally advanced diseases, severe post-operative morbidity and mortality rates were observed. Therefore, the involvement of adjacent vascular structures in pancreatic cancer is still considered inoperable by most surgeons. In recent years, publications from high-volume centers have become the basis for new discussions on the applicability of superior mesenteric and portal venous resections with acceptable complication rates (3). Although the resection of venous structures in pancreatic cancer and their impact on survival has gained acceptance, the resection of arterial structures is remains the center of discussion. However, there are no studies in literature supporting the non-resection of arterial structures in actuality. About 30% of pancreatic cancers are located in the pancreatic body or tail, and cancer in the pancreatic body leads to early celiac and main hepatic artery invasion due to anatomic proximity (4). According to the current guidelines, in cancer cases located in the body and tail of the pancreas, the involvement of the celiac and main hepatic arteries is considered a criterion for non-resectability. However, splenic artery involvement is not included in the inoperability criteria (5).

The first celiac artery resection to treat cancer was described by Appleby in 1953 (6). Appleby identified the presence of adequate hepatic artery flow after celiac artery resection with distal pancreatectomy and splenectomy in a patient with locally advanced gastric cancer. Nimura (7) adapted the surgical technique described by Appleby for the treatment of pancreatic cancers. Hepatic artery flow after celiac artery resection is achieved through the pancreaticoduodenal arc originating from the superior mesenteric artery. Although there are no comparative studies on the contribution of celiac artery resection for the survival period, promising results were obtained in the Almano (8) and Hartwig (9) series in terms of post-operative complications and survival. Furthermore, the reconstruction of intraoperative hepatic arterial flow after celiac artery resection is essential. Wu et al. (10) reported that elevated transaminase levels, cholecystitis, and gastric ulcer incidences were detected post-operatively, despite adequate hepatic artery flow through the pancreaticoduodenal arc after celiac artery resection. The presence of intraoperative hepatic artery pulsation and no macroscopic discoloration in all these complications indicate that there may be limitations in determining the adequacy of hepatic artery flow. Excessive lymphatic dissection and resection of border plexuses may cause liver ischemia in the post-operative period due to arterial vasospasm. Therefore, hepatic artery reconstruction, even in the presence of sufficient vascular flow, is thought to reduce gastric and hepatic dysfunction and prevent complications (11). Currently, hepatic artery flow can be detected using intraoperative Doppler USG and hepatic venous oxygenation rather than macroscopical evaluation by pulsatility and discoloration of the liver (12). Several different techniques for hepatic artery reconstruction have been described to date. In addition to end-to-end reconstruction, the middle colic artery as well as the saphenous vein or prosthetic graft (GORE-TEX®) can be used for the reconstruction of the gastroepiploic artery (13). Machado et al. (14) defined the iliac–hepatic artery revascularization technique using a prosthetic (Dacron®) hepatic artery reconstruction graft. Complications that may be caused by celiac artery resection can be prevented through preoperative celiac artery embolization. Although collateral development in the pancreaticoduodenal arc can be achieved with celiac artery embolization, it should be performed only in patients to be resected 1–2 days prior to the surgery (15).

In our case, pancreatic cancer originating from the pancreatic body characterized by main hepatic and celiac artery invasion was detected. Upon showing response to preoperative neoadjuvant treatment, surgical treatment was recommended to ensure maximum survival time. Main hepatic artery clamping was performed before celiac artery resection. Meanwhile, as intraoperative Doppler USG scan revealed adequate hepatic artery flow, celiac artery resection and total gastrectomy were added to distal splenopancreatectomy. Due to invasion of the posterior wall of the stomach by the mass in the pancreas, we decided that removal with total gastrectomy rather than preservation of left gastric artery by reconstruction would be more suitable for reaching the goal of R0 resection. Preoperative celiac artery embolization was not performed on our patient, as at centers where intraoperative USG and vascular reconstruction can be performed frequently, possible complications arising from embolization can be avoided. Total pancreaticoduodenectomy was recommended based on the finding that the tumor remained in the surgical margin according to the intraoperative frozen section examination. We decided to perform iliac–hepatic bypass for hepatic artery reconstruction via ligation of the gastroduodenal artery as other reconstruction methods required total aortic clamping to achieve adequate artery flow rate. This method was preferred in our case with a history of acute renal failure, owing to its ease of application and to avoid additional morbidity. Our patient completed the post-operative adjuvant therapy. He remains cancer-free and is in his 22nd post-operative month.


Vascular resections in pancreatic cancers have high rates of morbidity and mortality. However, due to the advanced anesthesia and surgical techniques in high-volume centers, complex reconstructive techniques can be performed with acceptable morbidity and mortality rates.

Cite this paper as: Özsoy M, Şahin E, Yavuz M, Özsoy Z, Okur N, Şahin S, et al. Alternative hepatic arterial reconstruction technique in case of total pancreaticoduodenectomy after celiac artery resection in pancreas cancer (appleby): Iliac–hepatic bypass. Turk J Surg 2018; 10.5152/turkjsurg.2018.3983.

Peer Review

Externally peer-reviewed.

Author Contributions

Concept - M.Ö., M.Y.; Design - Z.Ö.; Supervision - Y.A., S.Y.; Resource - S.Ş.; Materials - N.O.; Data Collection and/or Processing - E.Ş., M.Ö.; Analysis and/or Interpretation - Y.A.; Literature Search - Z.Ö.; Writing Manuscript - Z.Ö.; Critical Reviews - S.Y.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.


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