Abstract
Purpose: In this study we aimed to present our incidental malignancy rates in patients who were operated due to goiter.
Patients and Methods: The records of 114 patients who underwent surgery due to goiter between the years 2008–2009 were examined, retrospectively. Of the patients, 96 were women (84.21%), and 18 were men (15.78%).The mean age was 44.72±11.32 years.
Results: Postoperative histopathological examination results were malignant in 16 patients (14.03%); 12 (75%) of these were papillary carcinoma, 3 (18.75%) were follicular carcinoma and 1 (6.25%) was medullary carcinoma. The overall malignancy rate was 14.03%.
Conclusion: We think that malignancy rates will increase, as the experience of cytologists increases. In conclusion, more extended surgical resections should be preferred by the surgeon for the treatment of benign nodular goiter.
Keywords:
Thyroid nodule, fine needle aspiration biopsy, ultrasonography
References
1Pappalardo G, Guadalaxara A, Frattaroli FM et al. Total compared with subtotal thyroidectomy in benign nodular disease: personal series and review of published reports. Euro J Surg 1998;164:501–506.
2Koyuncu A, Dokmetas HS, Turan M, et al. Comparison of different thyroidectomy techniques for benign thyroid disease. Endocrine J 2003:50.723-727.
3Hannan AS. The magnificent seven: a history of modern thyrod surgery. Int J Surg 2006;4:187- 191.
4Alfred A, Simental JR, Myers EN. Thyroidectomy: Technique and applications. Oper Tech Otalaryngol Head Neck Surg 2003;14:63-73.
5Cusich EL, Krukowski ZH, Macintoch CA. Risk of neoplasia and malignancy in dominant thyroid swelling. BMJ 1991; 303: 20-24.
6Duh QY, Clark OH. Factors influencing the growth of normal and neoplastic thyroid tissue. Surg Clin North Am 1987; 67:
7Anderson PE, Hurley PR, Rosswick P. Conservative treatment and long-term prophylactic thyroxine in the prevention of recurrence of multinodular goiter. Surg Gynecol Obstet 1990; 171: 309.
8Gharib H. Changing concepts in the diagnosis and management of thyroid nodules. Endocrinol Metab Clin North Am 1997; 26: 777.
9Pingitore R, Vignati S, Bigini D, Ciancia EM. Post-operative examination of 2930 thyroid glands: observations on primary carcinoma. insidental carcinoma and the preoperative diagnostic assessment of thyroidectomy for cancer. Pathologica 1993; 85: 591-605.
10Ito Y, Uruno T, Nakano K, et al. An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid. Thyroid 2003; 13:381-387.
11Carlini M, Giovannini C, Castaldi F, et al. High risk for microcarcinoma in thyroid benign diseases. Incidence in a one year period of total thyroidectomies. J Exp Clin Cancer Res 2005; 24:231-236.
12Dietlein M, Luyken WA, Schicha H, Larena- Avellaneda A. Incidental multifocal papillary microcarcinomas of the thyroid: is subtotal thyroidectomy combined with radioiodine ablation enough? Nucl Med Commun 2005; 26:3-8.
13Kovács GL, Gonda G, Vadász G, et al. Epidemiology of thyroid microcarcinoma found in autopsy series conducted in areas of different iodine intake. Thyroid 2005; 15:152-157.
14Neuhold N, Kaiser H, Kaserer K. Latent carcinoma of the thyroid in Austria: a systematic autopsy study. Endocr Pathol 2001; 12:23-31.
15Harach HR, Franssila KO, Wasenius VM. Occult papillary carcinoma of the thyroid. A “normal” finding in Finland. A systemic autopsy study. Cancer 1985;56:531-538
16Frates MC, Benson CB, Doubilet PM, et al. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clini Endocrinol Metab 2006;91:3411–3417.
17Grant CS, Hay ID, Gough IR, et al. Longterm follow up of patient with benign thyriod FNA cytologic diagnosis. Surgery 1989; 106: 980.
18Frates MC, Benson CB, Charboneau JW, et al. Management of thyroid nodules detected at US: Society of Radiologist in Ultrasound Consensus Conferences Statement. Radiology 2005: 237; 794-800.
19Kraimps J.L, Marechaud R, Gineste D et al. Analysis and prevention of recurrent goiter. Surgery Gynecol Obstet 1993; 176: 319–322.
20Bron L.P, O'Brien C. J. Total thyroidectomy for clinically benign disease of the thyroid gland. Br J Surg 2004; 91: 569– 574.
21Müler P. E, Kabus S, Robens E et al. Indications, risks, and acceptance of total troidectomy for multinodular goiter. Surg Today 2001;31: 958–962.
