The Effects of Somatostatin and PGE Analogs on Anastomosis Healing in Rats with Small Bowel Obstruction
Dr. Anıl ÇUBUKÇU, Dr. Metin ERTEM, Dr. Sabrı ERGÜNEY, Dr. İsmail HAMZAOĞLU
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İSTANBUL
In this experimental study we investigated the effects of SMS 201-995 and PGE1 analogue misoprostol on the healing of intestinal anastomosis performed in an obstructed bowel model in rat. Three groups of 10 rats each were constituted. One group received misoprostol 200ug/kg, the second group SMS 201-995 2ug/kg; and the last group 1 cc salına subcutaneously, beginning 8 hours after the onset of obstruction until sacrifice. The rats were reoperated 24 hours after the ileal ligation and the ligated segment was resected and anastomosed. On the 5th postoperative day the rats were killed and the anastomosis healing evaluated by the measurement of bursting pressure and hydroxyproline concentration. It was found that SMS 201-995 had no any effect, whereas misoprostol influenced the healing process positively.
Keywords: Small bowel obstruction, Anastomosis healing, Prostaglandine, Somatostatine