Effect of Single Dose Prophylactic Antibiotic in Preventing Wound Infection in Nonperforating Acute Appendicitis: Randomized Study
Dr. Orhan DEMİRCAN, 1 Dr. Yalçın KEKEÇ, 1 Dr. Emin Uğur ERKOÇAK, 1 Dr. Akgün YAMAN, 2 Dr. İsmail Hakkı DÜNDAR, 3 Dr. Süha DEMİRTAŞ1
1Çukurova Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, ADANA
2Çukurova Üniversitesi Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, ADANA
3Çukurova Üniversitesi Tıp Fakültesi, Enfeksiyon Hastalıkları Anabilim Dalı, ADANA
A prospective, randomized, clinical study was performed to determine the efficacy of preoperative single dose systemic antibiotic in preventing wound infection after emergency appendectomy for acute nonperforating appendicitis. 81 patients were operated with a diagnosis of acute appendicitis, 40 of these patients received 1 g of ceftriaxone before undergoing operation. The patients were divided into two groups; group 1 (ceftriaxone, n=40), group 2 (didn't receive antibiotic, n=41). The two groups were similar with regard to age, sex, duration of preoperative symptoms, duration of operation, patologlc condition of appendix. The overall Incidence of wound Infection in the study was 9.8 %. The infections rates were group 1 2.5 % and group 2 17 %. Cost analysis identified a net savings 56290 TL per patients with the use of prophylactic antibiotic. This study showed a significant reduction of the incidence of wound infection in patients receiving single dose ceftriaxone prophylaxis.