Reticıdo-Endothelial Functions in Obstructive Jaundice
Dr. M. Faik ÖZÇEÜK1, Dr. Salih PEKMEZCİ1 Dr. Levent KABASAKAL2, Kim. Yük. Müh. Tülay CANSIZ2, Dr. Kutlan ÖZKER
1İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Genel Cerrahi ABD, İSTANBUL
2İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Nükleer Tıp ABD, İSTANBUL
Abstract
Sepsis is a major cause of mortality in patients with biliary obstruction (BO). Reticuloendothelial (RE) functions decrease with biliary obstruction. Hepatic and extrahepatic RE functions were examined with scintigraphic methods by using Tc-99m-phytate colloid in rats with one and four weeks biliary obstruction duration.
In rats with one and four weeks biliary obstruction groups hepatic uptake of colloid was not different from the sham operated group (p>0,05). Whereas uptake of colloid In spleen and lungs increased significantly in one and four weeks of biliary obstruction (p<0,01 and p<0,001 respectively).
However by considering hepatosplenomegaly due to biliary obstruction and by calculating activity percentage per gram tissue for each organ the following were assessed. In biliary obstruction groups compared to the sham operated group hepatic activity significantly decreased (p<0,01) (sham operated group % 8,9 ± 0,6 1 week BO % 7,9 ± 0,3 and 4 week BO % 7,5 ± 1), whereas spleen (sham operated group % 1,6 ± 0,7, 1 week BO % 2,3 ± 0,2 (p<0,05) and 4 week BO % 2,9 ± 0,8 (p<0,01) and lung activities (sham operated group % 0,21 ± 0,006, 1 week BO % 0,27 ± 0,04 (p<0,01) and 4 week BO (p<0,001) significantly increased.
As the results of our investigation decrease in hepatic and increase in spleen and lung RE activities in early biliary obstruction was concluded.