THE ROLE OF OXYGEN FREE RADICALS AND RADICAL SCAVENGERS IN STRESS INDUCED GASTRIC ULCERATIONS IN RATS
MEHMET ALİ GÜRSOY1, MURAT KAYABALI1, HOVSEP HAZAR1, ESİN KOTİLOĞLU2
1İstanbul Üniversitesi Tıp Fakültesi, Genel Cerrahi A.B.D./İSTANBUL
2İstanbul Üniversitesi Deneysel Tıp Araştırma ve Uygulama Merkezi (DETAM), A.B.D./İSTANBUL
In this experimental study we tried to evaluate the role of oxygen free radicals (OFR) which are responsible f or tissue damage in ischemic conditions and OFR scavengers in stress induced gastric ulceration. A total of 46 rats were grouped in 5: A control group, stress group, stress+scavenger (namely allopurinol, DMSO, SOD).
MDA, which is a metabolyte formed after peroxidation of the lipids of cell membran with the influence of OFR was found to be significantly high in the stress group compared to control group. This may indicate that accumulated OFR in gastric mucosal cell in stress is hazardous. MDA levels were significantly lowered in groups where scavengers were administered. In histopathologic examinations, there were extensive mucosal erosions in stress group, tike the scavenger groups. However in SOD group the erosions were significantly superficial unlike other scavengers. We concluded that OFR may not take a dominant role in stress induced gastric lesions but SOD may be effective in prophylaxis.