THE EFFECT OF SURGICAL TRAUMA ON SERUM LEVELS OF IMMUNOGLOBULIN, COMPLEMAN AND FIBRINOGEN
N ZAFER UTKAN, SELÇUK ARDA, N ZAFER CANTÜRK, FEVZİ İÇLİ
Cumhuriyet Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, SİVAS
We evaluated the effect of surgical trauma on serum levels of immunoglobulin, compleman and fibrinogen in 30 operated patients with or without cancer. As IgM and IgG significantly fell on all cases in 24 hours after operation (p<0.01), IgA reduction was statistically important in only cancer group (p<0.01), but IgG and IgM levels were coursed significantly low until postoperative 120th hour (p<0.05). These changes almost reached preoperative levels in the other cases. Decrease in first postoperative 24 hours and following increase until 120th hour on the levels of C3c were significant only in cancer group (p<0.01). While fibrinogen levels increased due to surgical trauma from 24th hour to 120th hour in cancer patients, these responses on the other patients were seen in first 24 hours (p<0.01). The reduction in C3c, IgG, IgM and IgA levels was significant, but did not extend below the normal levels.
These result show that the cancer patients were not in additional risk.