MUHAMMED GHAEMİ1, A ÖZDEMİR AKTAN1, CUMHUR YEĞEN1, ASIM CİNGİ1, İMER OKAR2, RIFAT YALIN1

1Marmara Üniversitesi Tıp Fakültesi, Genel Cerrahi, ABD, İSTANBUL
2Marmara Üniversitesi Tıp Fakültesi, Histoloji ve Embriyoloji ABD, İSTANBUL

Abstract

In previous studies it has been shown that when CPT is used systematically, it is able to bind free oxygen radicals and increase the endothelin concentration, thus plays a preventive role in ischemic changes in kidneys, liver and small intestine. The aim of this study is to clarify the role of CPT when added to Euro Collins solution in the preservation of kidneys. The study has been performed on 3 groups, each containing 6 tats. Ringer lactate, EuroCollins and EuroCollins enriched with CPT (5 mg/ml) were perfused to group 1, 2 and 3 respectively. Then their left kidneys were removed and preserved in the same solutions under 4°C temperature. Biopsies were taken with time intervals and studied under electron microscope. While great damage was confirmed in the 3rd hour in group 1, the same damage was seen in the 6th hour in the 2nd group. Biopsies which are taken at 6th hour in group 3 showed less damage when compared with group 2. The morphologic changes seen under electron microscope made us to believe that the addition of CPT to preservation solutions helps in delaying tissue damage.

Keywords: CAPTOPRIL, KIDNEY