THE ANALYSIS OF PROGNOSTIC FACTORS IN BREAST CANCER PATIENTS TREATED WITH CONSERVATIVE THERAPY

Abstract

The medical records of 84 patients treated with conservative therapy for early breast cancer were reviewed retrospectively. The median follow-up was 37 (13-81) months. Quadrantectomy plus axillary dissection had been performed in 47(56%) patients, lumpectomy plus axillary dissection in 20(23.8%)and lumpectomy in 17(20.2%) patients. There were 8 (9.5%) local recurrences. The rates of 5-yearoverall survival and 5-year disease-free survival were 92% and 71%, respectively. In univariate analysis of prognostic factors for local recurrence surgical margins and type of surgery were significant. In univariate analysis of the same parameters for distant recurrence surgical margins, presence of local recurrence and pathological axillary status were significant. Multivariate analysis showed that the most important prognostic factor for local recurrence was status of surgical margins and those for distant recurrence were surgical margins and pathological axillary status. In conclusion breast conserving therapy provides similar survival results to traditional therapy of breast cancer and negative surgical margins are important in the prognosis of the patients.