PROSTAGLANDINE-E2 AND I2 DIFFERENCES IN HYPERTHYROIDISM BEFORE AND AFTER MEDICAL TREATMENT
ERDAL KAYHAN, ENGİN OK, ERDOĞAN SÖZÜER, MUSTAFA KEREK
Erciyes Üniversitesi Tıp Fakültesi, Genel Cerrahi ABD, KAYSERİ
Prostaglandins (PG) are local hormones secreted from different kinds of cells. They are secreted in the pathologic processes of the body and have vasodilator effects, Aim: To investigate the levels of prostaglandin E; and L, which reflected the general characteristics of PGs on the patients influenced with hyperthyroidism. Materials and Methods: In this prospective study, we compared the levels of plasma and urine PGE2and PGI2 in a group with Basedow disease and in other group with multinodüler goitre. This comparative study was performed before and after treatment. As patients with Basedow disease were treated medically for6 months including propylthiourasil 150-300 mg/day and propranolol 80 mg/day and the other patients with multinodular goitre underwent operation. Results: Plasma PGE2, PGI2 and urine PGE2 levels were significantly high in the study group before treatment compared with the levels of after treatment in Basedow patients (p<0.05) but PGI2 levels were not statistically different between study and control group (p>0.05). There was no statistical difference between plasma and urine PGE2 and PG12 levels in control group (p>0.05). Only significant difference was found PGE2 levels between before and after treatment in Basedow patients (p<0.05). Conclusions: The synthesis of prostaglandin's enhanced locally into the thyroid gland and peripheral tissues in hyperthyroidism. The enhancement in synthesis of prostaglandins may be responsible for increased vascularity of the thyroid gland and systemic clinical and pathological changes in cases of hyperthyroidism.
Keywords: HYPERTHYROIDISM, PROSTAGLANDIN E2, PROSTAGLANDIN L2