Syringocystadenoma papilliferum located at the nipple: Description of an extremely rare case with review of the literature
Yaşar Subutay Peker1, Murat Urkan1, Salih Hamcan2, Ali Fuat Çiçek3, Mehmet Ali Gülçelik1
1Clinic of General Surgery, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey
2Clinic of Radiology, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey
3Clinic of Pathology, University of Health Sciences, Gülhane Training and Research Hospital, Ankara, Turkey
Syringocystadenoma papilliferum (SCAP) is a rare, benign tumor of the apocrine sweat glands, and only two nipple-located SCAP cases have been reported. Very few cases of malignant transformation and metastasis have been reported. We share our experience with SCAP located at the nipple that recurred with intraductal papilloma (IP). A female patient aged 26 years presented to our clinic with a mass at the posterior of the left nipple. The mass was excised, and the pathology report revealed SCAP. The patient had no recurrence for 1 year, but the mass recurred later in the same location. Re-excision was planned and conducted. Diagnosis of the second excised mass according to the pathology report was florid-type ductal epithelial hyperplasia and IP. SCAP may be located in female genitals, extremities, and trunk but these are rarer than in the head and neck. This is the third case reporting SCAP at the nipple. SCAP may be related to nevus sebaceous, resulting in basal cell carcinoma or syrigocystadenocarcinoma papilliferum; however, no data have been reported about the relation of SCAP with IP. The relation may be due to microscopic characteristics of SCAP, including the presence of papillary processes between two epithelial alignments. As a conclusion of this case presentation, SCAP of the nipple must be followed up for IP transformation or recurrence. Further evaluation may be needed for this dark side of the rare and little-known pathological entity; however, because of its rareness, it seems troublesome to diagnose.
Keywords: Intraductal papilloma, syrigocystadenocarcinoma papilliferum, syringocystadenoma papilliferum
Cite this article as: Peker YS, Urkan M, Hamcan S, Çiçek AF, Gülçelik MA. Syringocystadenoma papilliferum located at the nipple: Description of an extremely rare case with review of the literature. Turk J Surg 2019; 35 (2): 151-154
Written informed consent was obtained from patients who participated in this study.
Consept - Y.S.P.; Design - Y.S.P.; Supervision - M.A.G.; Resource - A.F.Ç.; Materials - Y.S.P.; Data Collection and/or Processing - S.H.; Analysis and Interpretation - Y.S.P.; Literature Search - M.U.; Writing Manuscript - Y.S.P.; Critical Reviews - M.A.G.
The authors whose names are listed immediately below certify that they have NO affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.
The authors declared that this study has received no financial support.