Turkish Journal of Surgery

Turkish Journal of Surgery

ISSN: 2564-6850
e-ISSN: 2564-7032


Yelda Dere1 , Sümeyye Ekmekçi2 , Serkan Çelik1 , Özgür İlhan Çelik1 , Özcan Dere3 , Volkan Karakuş4

1Department of Pathology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey
2Department of Pathology, Tepecik Training and Research Hospital, İzmir, Turkey
3Department of General Surgery, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey
4Department of Hematology, Muğla Sıtkı Koçman Training and Research Hospital, Muğla, Turkey


Objective: In cases presenting with lymphadenopathies (LAP) without a primary focus detected by simple radiological methods, the primary tumor can be diagnosed by a histopathological evaluation of the metastatic lymph nodes. We aimed to discuss the nonhematological malignancies presenting with lymphadenopathies and the histopathological results for primary tumors.
Material and Methods: In this retrospective study, cases diagnosed with metastasis in excisional lymph nodes between January 2013 and June 2016 were assessed for a histopathological diagnostic approach
Results: Among 632 lymph node biopsies, a total of 21 cases, involving 12 male and 9 female patients with a mean age of 57.23 y (range, 33–92 y), of nonhematological solid tumors were included. The most common localizations of the involved lymph nodes were inguinal (n=8), axillary (n=6), cervical (n=4), and supraclavicular (n=3) region. The most common primary tumors were malignant melanoma (n=6), breast carcinoma (n=4), ovarian carcinoma (n=2), squamous cell carcinoma (n=2), and germ cell tumor (n=2). Others were papillary thyroid carcinoma, renal cell carcinoma, urothelial carcinoma, prostate adenocarcinoma, and endometrial adenocarcinoma.
Conclusion: Nonhematological malignancies presenting with lymphadenopathies are one of the most complicated cases for clinicians. The histopathological evaluation of the excisional metastatic lymph node biopsies is an important method because of cost effectiveness and easy applicability.

Keywords: Immunohistochemistry, lymph node metastasis, unknown primary tumor

Cite this paper as: Dere Y, Ekmekçi S, Çelik S, Çelik Öİ, Dere Ö, Karakuş V. Where do these guests come from? A diagnostic approach for metastatic lymph nodes. Turk J Surg 2018; 34: 131-136.


Ethics Committee Approval

Not required in this study.

Peer Review

Externally peer-reviewed.

Author Contributions

Concept - Y.D., S.E., V.K.; Design - Y.D., Ö.İ.Ç., S.Y.Ç.; Supervision - Ö.D., S.Y.Ç.; Resource - Y.D., Ö.D., V.K.; Materials - V.K., Ö.D.; Data Collection and/or Processing - Y.D., Ö.D., S.E., V.K., Ö.İ.Ç., S.Y.Ç.; Analysis and/or Interpretation - Y.D., S.E., S.Y.Ç., Ö.İ.Ç.; Literature Search - Ö.D., V.K., S.Y.Ç.; Writing Manuscript - Y.D., Ö.İ.Ç., S.Y.Ç., S.E.; Critical Reviews - V.K., Ö.İ.Ç., S.Y.Ç.; Other - Y.D., S.E., Ö.D.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.