Turkish Journal of Surgery

Turkish Journal of Surgery

ISSN: 2564-6850
e-ISSN: 2564-7032


Mustafa Ümit Uğurlu1, İpek Erbarut Seven2, Funda Eren2, Cumhur Yeğen1, Bahadır Mahmut Güllüoğlu1

1Department of General Surgery, Marmara University School of Medicine, İstanbul, Turkey
2Department of Pathology, Marmara University School of Medicine, İstanbul, Turkey


Anaplastic thyroid carcinoma is a highly lethal malignancy. Previously, only five cases of a noninvasive form of anaplastic thyroid carcinoma with excellent prognosis were reported. We report a case of a 68-year-old man who presented with a 3.8 cm thyroid nodule diagnosed by fine needle aspiration biopsy as poorly differentiated spindled and epithelial malignant cells. Lobectomy and isthmusectomy were performed, and the final diagnosis was microinvasive anaplastic thyroid carcinoma arising in a poorly differentiated carcinoma. The patient remains disease-free after six years, even after hemithyroidectomy and radiation treatment. Noninvasive/microinvasive anaplastic thyroid carcinoma appears to be a different disease entity from classical anaplastic thyroid carcinoma, with favorable prognosis and long disease-free survival.

Keywords: Thyroid, anaplastic thyroid carcinoma, microinvasion

Cite this paper as: Uğurlu MÜ, Erbarut Seven İ, Eren F, Yeğen C, Güllüoğlu BM. Minimally invasive thyroid anaplastic carcinoma with long survival. Turk J Surg 2018; 34(4): 319-322.


Peer Review

Externally peer-reviewed.

Author Contributions

Concept - M.U.U.; Design - M.U.U.; Supervision - F.E., C.Y., B.M.G.; Analysis and/or Interpretation - M.Ü.U., İ.E.S.; Literature Search - M.Ü.U., İ.E.S.; Writing Manuscript - M.Ü.U., İ.E.S.; Critical Reviews - F.E., C.Y., B.M.G.

Conflict of Interest

The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.