Coexistence of gastric multiple neuroendocrine tumors with unusual morphological features and gastric signet-ring cell carcinoma
1Department of General Surgery, Uludağ University School of Medicine, Bursa, Turkey
2Department of Surgical Pathology, Uludağ University School of Medicine, Bursa, Turkey
Keywords: Synchronous, gastric, mucin-producing, spindle, neuroendocrine tumor
The coexistence of signet-ring cell carcinoma and neuroendocrine tumors is very rare. We report a 57-year-old man who presented with a history of weight loss and nausea. Gastric mucosal biopsies obtained during gastrointestinal endoscopy revealed a gastric signet-ring cell carcinoma. The patient underwent a total gastrectomy with a standard D2 lymph node dissection. Ten individual tumors were detected in the resected specimen. Based on the histopathological and immunohistochemical findings, the final diagnosis was co-existing signet-ring cell carcinoma and neuroendocrine tumor. Spindle-shaped cells and extracytoplasmic mucin were noted in some tumor cells forming the neuroendocrine component. This case is a rare synchronous tumor because of its unusual neuroendocrine component.
Cite this paper as: Uğraş N, Sarkut P, Yerci Ö, Öztürk E. Coexistence of gastric multiple neuroendocrine tumors with unusual morphological features and gastric signet-ring cell carcinoma. Turk J Surg 2018; 34: 152-154.
Written informed consent was obtained from patient who participated in this study.
Concept - N.U., Ö.Y.; Design - N.U., Ö.Y.; Supervision - Ö.Y., E.Ö.; Funding - E.Ö.; Materials - N.U., P.S., E.Ö.; Data Collection and/or Processing - N.U., P.S., Ö.Y., E.Ö.; Analysis and/or Interpretation - N.U., Ö.Y., P.S.; Literature Review - N.U., P.S., Ö.Y.; Writer - N.U., Ö.Y.; Critical Review - Ö.Y., E.Ö.; Other - N.U. Conflict of Interest: The authors have no conflicts of interest to declare.
The authors declared that this study has received no financial support.