Turkish Journal of Surgery

Turkish Journal of Surgery

ISSN: 2564-6850
e-ISSN: 2564-7032


Nesrin Uğraş1, Pınar Sarkut2, Ömer Yerci1, Ersin Öztürk2

1Department of General Surgery, Uludağ University School of Medicine, Bursa, Turkey
2Department of Surgical Pathology, Uludağ University School of Medicine, Bursa, Turkey


The coexistence of signet-ring cell carcinoma and neuroendocrine tumors is very rare. We report a 57-year-old man who presented with a history of weight loss and nausea. Gastric mucosal biopsies obtained during gastrointestinal endoscopy revealed a gastric signet-ring cell carcinoma. The patient underwent a total gastrectomy with a standard D2 lymph node dissection. Ten individual tumors were detected in the resected specimen. Based on the histopathological and immunohistochemical findings, the final diagnosis was co-existing signet-ring cell carcinoma and neuroendocrine tumor. Spindle-shaped cells and extracytoplasmic mucin were noted in some tumor cells forming the neuroendocrine component. This case is a rare synchronous tumor because of its unusual neuroendocrine component.

Keywords: Synchronous, gastric, mucin-producing, spindle, neuroendocrine tumor

Cite this paper as: Uğraş N, Sarkut P, Yerci Ö, Öztürk E. Coexistence of gastric multiple neuroendocrine tumors with unusual morphological features and gastric signet-ring cell carcinoma. Turk J Surg 2018; 34: 152-154.


Peer Review

Concept - N.U., Ö.Y.; Design - N.U., Ö.Y.; Supervision - Ö.Y., E.Ö.; Funding - E.Ö.; Materials - N.U., P.S., E.Ö.; Data Collection and/or Processing - N.U., P.S., Ö.Y., E.Ö.; Analysis and/or Interpretation - N.U., Ö.Y., P.S.; Literature Review - N.U., P.S., Ö.Y.; Writer - N.U., Ö.Y.; Critical Review - Ö.Y., E.Ö.; Other - N.U. Conflict of Interest: The authors have no conflicts of interest to declare.

Financial Disclosure

The authors declared that this study has received no financial support.