Increased interleukin 1 and tumor necrosis factor alpha levels after thyroid surgery

Abstract

Objective: The aim of this study was to consider levels of the proinflammatory cytokines IL-1 and TNFα after thyroid surgery.
Material and Methods: A total of 200 patients who underwent total thyroidectomy enrolled in this study. Drain fluid samples were taken. IL-1 and TNFα results and their relationship with other factors were analyzed.
Results: There was a positive correlation between IL-1 and hyperthyroidism (rs=0.614, p<0.001), operative time (rs=0.770, p<0.001), and excised thyroid volume (rs=0.829, p<0.001). Moreover, there was a positive correlation between TNFα and hyperthyroidism (rs=0.430, p<0.001), operative time (rs=0.392, p<0.001), and excised thyroid volume (rs=0.398, p<0.001).
Conclusion: The results of this study showed us that the parameters related to increased proinflammatory cytokine levels after thyroid surgery were hyperthyroidism, operative time, and excised thyroid volume, but this increase did not show us any clinical outcomes related to these parameters.

Ethics committee approval was received for this study from the ethics committee of İstanbul University İstanbul Faculty of Medicine.

Written informed consent was obtained from patients who participated in this study.

Externally peer-reviewed.

Concept - Y.E., S.Ö.; Design - S.M.; Supervision - Y.E.; Funding - Y.E.; Materials - Ü.T., K.D.P.; Data Collection and/or Processing - N.A., F.Y.; Analysis and/or Interpretation - B.Ö., O.A.; Literature Review - B.Ö.; Writer - B.Ö.; Critical Review - Y.E.

No conflict of interest was declared by the authors.

The authors declared that this study has received no financial support.